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目的探讨米非司酮联合利凡诺在中期妊娠引产中的临床效果。方法选取中期妊娠要求引产的产妇50例,按照双盲法随机分为观察组和对照组各25例,观察组给予米非司酮150mg口服,利凡诺100mg经腹羊膜腔注入,对照组单独给予利凡诺100mg羊膜腔内注射,比较2组产妇子宫出血量、胎盘排出时间、宫缩时间、总产程、疼痛评分及并发症发生率。结果观察组子宫出血量、胎盘排出时间、宫缩时间、总产程、疼痛评分等均明显少于对照组,差异有统计学意义(P<0.05);观察组引产成功率为100%(25/25),高于对照组的92%(23/25),但差异无统计学意义(P>0.05);观察组并发症发生率为12%,低于对照组的36%,差异有统计学意义(P<0.05)。结论中期妊娠引产中联合采用利凡诺和米非司酮的效果良好,安全性高,值得临床推广应用。
Objective To investigate the clinical efficacy of mifepristone and rivanol in induction of labor during the second trimester of pregnancy. Methods Fifty pregnant women required induction of labor during the second trimester of pregnancy were randomly divided into observation group (25 cases) and control group (25 cases). Mifepristone 150 mg orally, rivanol 100 mg Rivinola 100mg was administered intra-peritoneally to compare the two groups of maternal uterine bleeding, placenta discharge time, contractions time, total labor, pain score and complication rate. Results The amount of uterine bleeding, the time of placenta discharge, the time of contractions, the total labor and the pain score in the observation group were significantly less than those in the control group (P <0.05). The success rate of induction of labor in the observation group was 100% (25 / 25), which was higher than that of control group (92/25), but the difference was not statistically significant (P> 0.05). The complication rate in observation group was 12%, which was lower than that in control group (36%), the difference was statistically significant Significance (P <0.05). Conclusions The combination of Rivarovir and mifepristone in induction of labor in mid-term pregnancy is effective and safe, and is worthy of clinical application.