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目的探讨血清可溶性细胞间粘附分子-1(sICAM-1)在肾移植术后免疫学监测中的价值.方法采用酶联免疫吸附法(ELSA)动态监测56例肾移植患者术后sICAM-1水平的变化.结果肾移植患者术后sICAM-1水平呈规律性变化,急性排斥反应组sICAMI-1水平(390.6±91.0)ng/ml明显高于移植肾功能稳定组(137.3±16.8)ng/ml和CsA肾中毒组(132.7±24.8)ng/ml,差异非常显著(p<0.01),抗排斥反应治疗有效后sICAM-1逐渐降至正常水平.CsA肾中毒组,sICAM-1水平无明显变化.结论肾移植术后动态监测SICAM-1水平的变化,有助于急性排斥反应的诊断和鉴别诊断及抗排斥反应的疗效评价、sICAM-1可以作为肾移植术后急性排斥反应的免疫学监测指标之一.
Objective To investigate the value of serum soluble intercellular adhesion molecule-1 (sICAM-1) in immunological surveillance after renal transplantation.Methods The levels of sICAM-1 in 56 renal transplant recipients were detected by enzyme linked immunosorbent assay (ELSA) (SICAM-1) levels in the patients with renal allograft (390.6 ± 91.0) ng / ml were significantly higher than those in the stable renal graft (137.3 ± 16.8) ng / ml and CsA nephrotoxicity group (132.7 ± 24.8) ng / ml, the difference was significant (p <0.01), sICAM-1 gradually decreased to normal level after anti-rejection treatment was effective. Change.Conclusion Dynamic monitoring of SICAM-1 level after renal transplantation is helpful for the diagnosis and differential diagnosis of acute rejection and the evaluation of anti-rejection efficacy.It can be used as immunology of acute rejection after renal transplantation One of the monitoring indicators.