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目的 :为了解药物性肝病的病因和临床表现 ,对 87例因药物性肝病住院的患者进行调查分析。结果 :药物性肝病的病因呈多样性 ,其中 33例 (38% )为抗结核药物所致 ,16例 (18 4% )为抗肿瘤药引起 ,余 38例为各类其他药物所致。 85例 (98% )表现为急性型 ,46例 (5 3% )伴有血清胆红素升高。 8例死于肝功能衰竭 ,均有乙型肝炎慢性感染史。结论 :使用损肝药物要严密监测肝功能
Objective: To understand the etiology and clinical manifestations of drug-induced liver disease, 87 patients hospitalized with drug-induced liver disease were investigated. Results: The causes of drug-induced liver disease showed a diversity. Among them, 33 (38%) were caused by antituberculotics, 16 (18 4%) were caused by antineoplastic drugs and 38 were all kinds of other drugs. 85 cases (98%) showed acute type, and 46 cases (53%) had elevated serum bilirubin. 8 patients died of liver failure, have a history of chronic hepatitis B. Conclusion: The use of liver damage drugs should be closely monitored liver function