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目的:观察17aα-D-高炔雌二醇-3-乙酯及其联合化疗对EC901食管癌的抑制作用。方法:将接种EC901瘤细胞的裸鼠分为对照组、17aα-D-高炔雌二醇-3-乙酯组、5-氟尿嘧啶(5-Fu)组、17aα-D-高炔雌二醇-3-乙酯联合5-Fu组,连续给药9d,分别检测肿瘤抑制率、外周血常规、骨髓有核细胞计数、肿瘤病理等指标。结果:17aα-D-高炔雌二醇-3-乙酯治疗组瘤重明显小于对照组,联合5-Fu组肿瘤生长分别低于5-Fu组和照射组。结论:17aα-D-高炔雌二醇-3-乙酯联合5-Fu对EC901食管癌的抑制具有增效作用。
Objective: To observe the inhibitory effect of 17aα-D-high ethinyl estradiol-3-ethyl ester and its combination chemotherapy on EC901 esophageal cancer. METHODS: nude mice inoculated with EC901 tumor cells were divided into control group, 17aα-D-high alkyside-3-ethyl ester group, 5-fluorouracil (5-Fu) group, 17aα-D-high ethinyl estradiol Ethyl-3-ethyl ester combined with 5-Fu group, continuous administration for 9 days, respectively, tumor inhibition rate, peripheral blood routine, bone marrow nucleated cell count, tumor pathology and other indicators. RESULTS: The tumor weight of 17aα-D-high ethinyl estradiol-3-ethyl ester treatment group was significantly lower than that of the control group. The tumor growth of the combined 5-Fu group was lower than that of the 5-Fu group and the irradiation group, respectively. Conclusion: The combination of 17aα-D-high ethinylestradiol-3-ethyl ester combined with 5-Fu has a synergistic effect on the inhibition of EC901 esophageal cancer.