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目的 探讨肝脏移植术中无肝期下腔静脉阻断的可行性。方法 以大鼠为实验对象 ,分别阻断肝门和同时阻断肝门、肝下下腔静脉 0min、30min和 6 0min ,于门静脉和下腔静脉分别取血行生化指标的检测 ,了解无肝期下腔静脉阻断对机体生化指标的影响。结果 无肝期阻断下腔静脉可以①使门静脉血清K+的升高更为明显 ,且与阻断时间的延长呈正比 ;②使再灌注后体循环中的谷丙转氨酶 (SGPT)和谷草转氨酶 (SGOT)明显升高 ,但与阻断方式和时间无关 ;③除肌酐 (Cr)浓度随阻断时间延长而升高外 ,尿素氮 (BUN)的变化不大。结论 肝移植的无肝期间可以短时间阻断下腔静脉
Objective To investigate the feasibility of anhepatic inferior vena cava occlusion during liver transplantation. Methods The rats were used as the experimental subjects to block the portal of the liver and block the hepatic portal and subhepatic inferior vena cava at 0, 30 and 60 minutes respectively. The blood samples were collected from the portal vein and the inferior vena cava for biochemical detection. Effects of Inferior Vena Cava Blockage on Biochemical Indexes. Results In the anhepatic phase, the inferior vena cava could ① make the elevation of portal vein serum K + more obvious, and it was proportional to the prolongation of the blocking time; ②the systolic and diastolic velocities of alanine aminotransferase (SGPT) and aspartate aminotransferase SGOT) was significantly increased, but not related to the time and the way of blockade. (3) Except for creatinine (Cr), the concentration of creatinine increased with the prolongation of blocking time. Conclusion During the anhepatic period of liver transplantation, the inferior vena cava can be blocked for a short time