论文部分内容阅读
色素上皮源性因子(PEDF)是一种丝氨酸蛋白酶抑制剂,其具有抗炎症反应、抗氧化应激、抑制新生血管生成、神经营养及神经保护等功能。越来越多的研究显示,PEDF与糖尿病性肾病(DN)密切相关,PEDF可以抑制细胞间黏附分子-1(ICAM-1)、单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和血管内皮生长因子(VEGF)等炎症因子的表达,提示其具有抗炎症反应的活性。PEDF也具有促进内皮细胞凋亡、抑制纤维化等对肾脏的保护作用。因此,PEDF有望成为DN治疗的一种新选择。
Pigment epithelial-derived factor (PEDF) is a serine protease inhibitor that has anti-inflammatory, anti-oxidative stress, antiangiogenic, neurotrophic and neuroprotective functions. More and more studies have shown that PEDF is closely related to diabetic nephropathy (DN). PEDF can inhibit ICAM-1, MCP-1, tumor necrosis The expression of inflammatory cytokines, such as TNF-α, IL-6 and VEGF, suggests that they have anti-inflammatory activity. PEDF also has to promote endothelial cell apoptosis, inhibition of fibrosis and other protective effect on the kidneys. Therefore, PEDF is expected to become a new treatment for DN.