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由L-半胱氨酸乙酯与二硫化碳在Et3N存在下反应，得到光学活性（R）－四氢噻唑－2－硫酮－4－羧酸乙酯，后者同3－（2－氧代环已基）丙酸在N，N－二环己基胺二亚胺（DCC）存在下反应，得到光学活性（R）－N－3－（2－氧代环己基）丙酰四氢噻唑2－硫酮－4－羧酯乙酯及光学活性的3－（2－氧代环己基）丙酸．用半经验的量子化学PM3方法研究反应物和产物的最优构型与电子结构．
Reaction of ethyl L-cysteinate with carbon disulfide in the presence of Et3N gave ethyl (R) -tetrahydrothiazole-2-thione-4-carboxylate which was reacted with 3- (2- (R) -N-3- (2-oxocyclohexyl) propionyl tetrahydrothiazole 2 is reacted in the presence of N, N-dicyclohexylaminediimine (DCC) Thione-4-carboxylate ethyl ester and optically active 3- (2-oxocyclohexyl) propionic acid. The semi-empirical quantum chemical PM3 method was used to study the optimal configuration and electronic structure of reactants and products.