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目的了解成都市健康儿童不同流行期手足口病病毒携带情况,为手足口病防控工作提供技术支持。方法采用分层随机抽样方法,抽取成都市120所托幼机构的758名健康托幼儿童,在手足口病发病高峰期、低谷期采用RTPCR检测健康儿童肠道病毒类型。结果流行期健康儿童肠道病毒阳性率为8.93%,非流行期阳性率为2.13%,差异有统计学意义(χ~2=17.70,P<0.01)。流行期健康儿童其他肠道病毒阳性率为7.44%,高于非流行期(2.13%)(χ~2=12.30,P<0.01)。流行期时城区健康儿童肠道病毒携带率(13.13%)高于郊区(2.89%)(χ~2=10.47,P=0.001);健康儿童其他肠道病毒携带率高于确诊病例(χ~2=28.26,P<0.01),CA16,EV71携带率低于确诊病例(P值均<0.01)。结论加强流行期城区托幼机构手足口病防控工作,积极开展手足口病健康儿童其他肠道病毒病原型别监测研究,警惕流行期健康儿童EV71携带情况,对控制手足口病流行具有重要意义。
Objective To understand the prevalence of HFMD in healthy children in different epidemic periods in Chengdu and to provide technical support for prevention and control of HFMD. Methods A stratified random sampling method was used to collect 758 healthy children and toddlers from 120 nurseries in Chengdu. RTPCR was used to detect the enterovirus types in healthy children at the peak and the trough of HFMD. Results The positive rate of enterovirus in healthy children during the epidemic period was 8.93%. The positive rate in non-epidemic period was 2.13%. There was significant difference (χ ~ 2 = 17.70, P <0.01). The positive rate of other enterovirus in healthy children during the epidemic period was 7.44%, higher than that in non-epidemic period (2.13%) (χ ~ 2 = 12.30, P <0.01). During the epidemic period, the carriage rate of enterovirus among healthy children in urban areas was higher than that in suburbs (2.89%) (χ ~ 2 = 10.47, P = 0.001). The carriage rate of other enteroviruses in healthy children was higher than that of confirmed cases = 28.26, P <0.01). The carrying rates of CA16 and EV71 were lower than those of confirmed cases (all P <0.01). Conclusion To strengthen the prevention and control of hand-foot-mouth disease in nurseries and kindergartens in urban areas during the epidemic period and to carry out the surveillance of other enterovirus pathogens in healthy children with HFMD. It is important to guard against the EV71 carrier in healthy children during the epidemic period. .