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观察高压氧对脑外伤后脑水肿及一氧化氮的影响。方法：建立大鼠液压脑外伤模型，采用生化、放免等方法观察脑外伤后不同时期高压氧（ＨＢＯ）治疗组和未治疗组血浆一氧化氮（ＮＯ）、脑组织ＮＯ、环磷酸鸟苷酸（ｃＧＭＰ）及脑组织含水量的变化，并进行病理学检查。结果：ＨＢＯ治疗组血浆ＮＯ、脑组织含水量、腋组织ＮＯ及ｃＧＭＰ较未治疗组均有不同程度下降（Ｐ＜０．０５）。脑组织含水量与血浆ＮＯ及脑组织ＮＯ、ｃＧＭＰ之间呈正相关关系（ｒ＝０．３４１４、０．３８１９、０．４８０４、Ｐ＜０．０５），病理检查可见ＨＢＯ治疗组脑组织损伤较轻。结论：ＨＢＯ能减轻脑外伤后脑水肿，并抑制脑外伤后ＮＯ的过量生成。ＨＢＯ减轻脑外伤后脑水肿的机制与ＮＯ有关。
To observe the effect of hyperbaric oxygen on brain edema and nitric oxide after traumatic brain injury. Methods: The model of traumatic brain injury in rats was established. The levels of nitric oxide (NO), NO, cyclic guanosine monophosphate (PGC) in brain tissue were detected by biochemical and radioimmunoassay methods in HBO-treated and untreated groups. (CGMP) and brain water content changes, and pathological examination. Results: The levels of NO, brain water content, NO and cGMP in axillary tissue of HBO treatment group were all decreased to some extent (P <0.05). There was a positive correlation between brain water content and NO and cGMP in plasma (r = 0.3414,0.3819,0.4804, P <0.05). Pathological examination showed that brain tissue injury in HBO treatment group was more significant light. Conclusion: HBO can reduce brain edema after traumatic brain injury and inhibit the excessive production of NO after traumatic brain injury. HBO to reduce cerebral edema after traumatic brain injury mechanism and NO.