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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者的血清降钙素原(PCT)和超敏C反应蛋白(hsCRP)水平变化及其诊断价值。方法选择2014年10月~2015年5月我院收治的60例COPD患者进行研究,按照患者病情状况分为急性加重期组和稳定期组,各30例,同时选择30例健康体检者作为对照组。分别采用发光免疫分析法定量测定PCT水平,速率散射比浊法检测hs-CRP水平。比较各组的PCT和hs-CRP水平,并观察AECOPD患者病情与以上指标的关系。结果急性加重组的血清PCT和hs-CRP水平显著高于稳定期组和对照组,差异有统计学意义(P<0.05)。稳定期组的PCT和hs-CRP水平高于对照组,差异有统计学意义(P<0.05)。AECOPD感染组的PCT和hs-CRP水平显著高于未感染组,差异有统计学意义(P<0.05)。结论 PCT和hs-CRP检验有利于对AECOPD患者的感染情况进行判定,诊断价值较高,值得临床推广应用。
Objective To investigate the changes of serum procalcitonin (PCT) and hsCRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their diagnostic value. Methods Sixty COPD patients admitted to our hospital from October 2014 to May 2015 were enrolled and divided into acute exacerbation group and stable group according to the patient’s condition, 30 patients in each group, and 30 healthy subjects were selected as control group. Luminescence immunoassay was used to quantify PCT levels, rate nephelometry hs-CRP levels. The levels of PCT and hs-CRP in each group were compared, and the relationship between the severity of AECOPD and the above indexes was observed. Results The levels of serum PCT and hs-CRP in acute exacerbation group were significantly higher than those in stable phase group and control group (P <0.05). The levels of PCT and hs-CRP in stable group were significantly higher than those in control group (P <0.05). The levels of PCT and hs-CRP in AECOPD infection group were significantly higher than those in non-infected group, the difference was statistically significant (P <0.05). Conclusions The PCT and hs-CRP test is beneficial to determine the infection of patients with AECOPD. The diagnostic value is high and worthy of clinical application.