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目的了解“大三阳”与“小三阳”患者血清中HBV-DNA定量、肝功能指标的相互关系及意义。方法选择2014年1-6月到武汉大学人民医院感染科就诊的651例乙型肝炎(乙肝)患者,检测其血清学指标“两对半”和生化指标8项。按血清学结果分为A(“小三阳”组)、B(“大三阳”组)、C(健康对照组)3组,对其检测结果进行分析。结果 A与B组患者的年龄、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)活力的差异有统计学意义(P<0.01)。随着HBV-DNA载量的增加,A和B组的ALT和AST水平相应升高。结论 “大三阳”患者肝功能损伤程度及HBV-DNA含量高于“小三阳”患者,但肝功能与乙肝感染病程不呈平行关系。
Objective To understand the relationship between serum HBV-DNA and liver function in serums of “Sanshyangyang” and “Sanyangyang” and its significance. Methods From January to June 2014, 651 patients with hepatitis B (hepatitis B) admitted to the Infectious Diseases Section of People ’s Hospital of Wuhan University were enrolled in the study. Serological markers, “two and a half” and 8 biochemical indexes were detected. The results of serology were divided into three groups: A (“Sanyang” group), B (“Sanyangyang” group) and C (healthy control group), and their test results were analyzed. Results There was a significant difference in the age, ALT and AST activity between patients in group A and group B (P <0.01). With the increase of HBV-DNA load, the levels of ALT and AST in groups A and B increased accordingly. Conclusions The degree of liver injury and the content of HBV-DNA in patients with “Sansheng Yang” are higher than those in patients with “Sanyangyang”. However, the relationship between liver function and the course of hepatitis B infection is not parallel.