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目的：探讨一氧化氮（ＮＯ） 、内皮素（ＥＴ） 在蛛网膜下腔出血（ＳＡＨ） 后急性脑血管痉挛（ＣＶＳ） 中的作用。方法：应用非开颅大鼠ＳＡＨ 模型，检测ＳＡＨ 前后基底动脉（ＢＡ） 管径改变，２４ ｈ 内大脑顶叶皮层局部脑血流量（ｒＣＢＦ） 、血中ＮＯ、ＥＴ 含量动态变化。结果：ＳＡＨ 后ＢＡ 管径明显缩小，在ＳＡＨ 后２４ ｈ 内ｒＣＢＦ 明显持续降低，血ＮＯ 含量自ＳＡＨ 后１ ｈ 开始持续低于术前值，而血ＥＴ 浓度则于ＳＡＨ 后立即高于术前值，并持续２４ ｈ 。结论：ＳＡＨ 后血ＮＯ 含量减低和ＥＴ浓度增加参与了急性ＣＶＳ 发生
Objective: To investigate the role of nitric oxide (NO) and endothelin (ET) in acute cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). Methods: The SAH model of non-craniotomy rats was used to detect the changes of the diameter of basilar artery (BA) before and after SAH, the changes of regional cerebral blood flow (rCBF) and NO, ET in blood in 24 hours. Results: After SAH, the diameter of BA was significantly reduced. The rCBF decreased significantly within 24 h after SAH. The content of blood NO decreased from 1 h after SAH, but was lower than preoperatively at 1 h after SAH. Value for 24 h. Conclusion: The decrease of blood NO and the increase of ET concentration after SAH are involved in the occurrence of acute CVS