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目的:立体选择性地合成(S)-2,4,6-三甲基苯丙氨酸。方法:2,4,6-三甲基苯甲酸还原生成2,4,6-三甲基苯甲醇(1),再溴化生成2,4,6-三甲基溴苄(2),所得溴苄和(S)-BPB-Ni-Gly络合物(3)缩合,经分离立体选择性地得到(S)-Tmp-BPB-Ni络合物(4),(4)经酸解得到(S)-2,4,6-三甲基苯丙氨酸(5)。结果:以52.8%的总收率立体选择性地合成得到(S)-2,4,6-三甲基苯丙氨酸。结论:本合成方法原料廉价易得、操作简单、反应收率高。
Objective: To synthesize (S) -2,4,6-trimethylphenylalanine in a stereoselective manner. Methods: 2,4,6-trimethylbenzoic acid was reduced to 2,4,6-trimethylbenzyl alcohol (1) and then brominated to 2,4,6-trimethylbenzyl bromide (2) (S) -Tmp-BPB-Ni complex (4) is obtained by condensation of benzyl bromide and (S) -BPB-Ni-Gly complex (3) (S) -2,4,6-trimethylphenylalanine (5). Results: The (S) -2,4,6-trimethylphenylalanine was stereoselectively synthesized in a total yield of 52.8%. Conclusion: The synthesis method is cheap and easy to use, the operation is simple and the reaction yield is high.