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目的介绍天然产物中羊毛甾烷型三萜类化合物的化学性质及生物活性研究概况及展望。方法以国内外发表的文献为依据,对近年以来从天然产物中发现的羊毛甾烷型三萜类化合物及其生物活性进行介绍。结果天然产物中羊毛甾烷型三萜类化合物以羊毛甾-8-烯型三萜(lanosta-8-enetypetriterpenes)为主,其生物活性主要表现为对多种肿瘤细胞的抑制作用、抗菌、抗病毒、抗炎镇痛以及在胚细胞发育过程中的调控作用。结论我国含有羊毛甾烷型三萜的天然产物资源丰富,具有较强生物活性,新药开发前景看好。
Objective To introduce the general situation and prospect of the chemical properties and biological activity of lanostane-type triterpenoids in natural products. Methods Based on the literature published at home and abroad, the lanostane-type triterpenes found in natural products and their biological activity were introduced. Results The lanosta-8-ene type triterpenoids (lanosta-8-ene type triterpenes) were the main products of natural products. The biological activity of the lanosta-8-ene triterpenoids was mainly manifested as inhibition of various tumor cells. Virus, anti-inflammatory and analgesic as well as in the regulation of blastocyst development. Conclusion The natural products containing lanostane-type triterpenes in our country are rich in resources and have strong biological activity. The prospects for the development of new drugs are promising.