【摘 要】
：
Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sono-photodynamic therapy(SPDT)provides alternative opportunities for
【机 构】
：
Cancer Metastasis Alert and Prevention Center,College of Chemistry,Fuzhou University,Fuzhou 350116,C
论文部分内容阅读
Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sono-photodynamic therapy(SPDT)provides alternative opportunities for clinical cancer therapy.Although signif-icant advances have been made in synthesizing new sensitizers for SPDT,few of them are successfully applied in clinical settings.The anti-tumor effects of the sensitizers are restricted by the lack of tumor-targeting spec-ificity,incapability in deep intratumoral delivery,and the deteriorating tumor microenvironment.The applica-tion of nanotechnology-based drug delivery systems(NDDSs)can solve the above shortcomings,thereby improving the SPDT efficacy.This review summarizes various sensitizers as sono/photosensitizers that can be further used in SPDT,and describes different strategies for enhancing tumor treatment by NDDSs,such as overcoming biological barriers,improving tumor-targeted delivery and intratumoral delivery,providing stimuli-responsive controlled-release characteristics,stimulating anti-tumor immunity,increasing oxygen sup-ply,employing different therapeutic modalities,and combining diagnosis and treatment.The challenges and prospects for further development of intelligent sensitizers and translational NDDSs for SPDT are also dis-cussed.
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