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目的:探讨首过期的64层VCT肺灌注成像对肺部结节的诊断意义。方法:对108例肺结节患者进行CT灌注扫描,测定肺结节的时间-密度曲线(TDC)、血容积(BV)、血流量(BF)、平均通过时间(MTT)和表面通透性(PS)的数值,并测量肺结节增强前的CT值、增强值和结节-动脉增强值之比(S/A)。标定结节的血管内皮生长因子(VEGF),评价肺结节CT灌注和增强指数与VEGF表达的相关性。结果:肺癌的灌注指数高于肺良性结节。良、恶性结节的TDC形态不同。结论:CT肺灌注成像可定量的评价肺结节的血流灌注特点,对肺部结节有较大的诊断及鉴别诊断意义。
Objective: To investigate the diagnostic significance of the first stage 64-slice VCT pulmonary perfusion imaging in pulmonary nodules. Methods: CT perfusion was performed in 108 patients with pulmonary nodules. The time-density curve (TDC), blood volume (BV), blood flow (BF), mean transit time (MTT) and surface permeability (PS), and the ratio of enhanced CT value to nodule-to-artery enhancement value (S / A) was measured before enhancement of pulmonary nodules. The nodular vascular endothelial growth factor (VEGF) was calibrated to evaluate the correlation between CT perfusion and enhancement index of lung nodules and VEGF expression. Results: Lung perfusion index was higher than benign pulmonary nodules. The TDC morphology of benign and malignant nodules is different. Conclusion: CT pulmonary perfusion imaging can quantitatively evaluate the perfusion characteristics of pulmonary nodules, which has great diagnostic and differential diagnostic significance for pulmonary nodules.