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作者用有机磷类的敌百虫作了预防性的现场试验。观察对象为定居于津巴布韦埃及血吸虫病和曼氏血吸虫病严重流行区的儿童。试验分为3个阶段进行,即1个初期治疗阶段及两个6个月为1期的预防阶段。每月作寄生虫学及血液学检查,并在试验前及在3个阶段中的每期结束时对该药作出评价。对相应组治疗期的每次药物剂量为7.5毫克/公斤体重,每2周给药1次,共3次;预防期的每次药物剂量相同,但为每4周给药1次。于治疗期结束后6周复查时,埃及血吸虫病患者的治愈率为60%。在这些继续接受此药化学预防的儿童中预防感染的效果是很高的,甚至在流行高峰季节中的感染程度也很低。仅作治疗而不予预防性给药的组中,其感染率则从11周时的40%持续上升至70周时
The authors made prophylactic field trials with organophosphate trichlorfon. Observations were for children who settled in the highly endemic area of schistosomiasis mansoni and schistosomiasis in Zimbabwe. The trial is divided into three stages, namely, an initial stage of treatment and two 6-month phase of prevention. The parasite and haematological tests are conducted monthly, and the drug is evaluated before the test and at the end of each of the three phases. Each drug dose for the corresponding group of treatment period was 7.5 mg / kg body weight, administered once every two weeks for a total of 3 doses; each dose of prophylaxis was the same but administered once every 4 weeks. At the 6th week after the end of the treatment period, the cure rate for schistosomiasis in Egypt was 60%. The effect of preventing infection in these children who continue to receive chemoprevention of this medicine is high, even with low prevalence during the peak season. In the treatment-only and non-prophylactic groups, the infection rate continued to increase from 40% at week 11 to 70 weeks