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AIM:To examine the calcium metabolism of colorectal cancer(CRC)in patients with colorectal cancer and control patients.METHODS:Seventy newly diagnosed CRC patients wereincluded.The healthy control group was age and gendermatched(n=32).Particular attention was devoted to therelationship between serum calcium of patients,and levelsof AFP,CEA,carbohydrate antigen 19-9(CA 19-9)(that couldbe considered as prognostic factors).Furthermore,theCa-sensing receptor(CaSR)gene A986S polymorphism wasinvestigated in these patients,as well as the relationshipbetween different CaSR genotypes and the data stated above.RESULTS:A lower level of ionized calcium(also correctedfor albumin)was found in the serum of CRC patients withnormal 25(OH)vitamin D levels.The ionized calciumconcentration was inversely correlated with the serum levelof CA.19-9.There was no difference in the distribution ofCaSR genotypes,between CRC patients and generalpopulation.The genotypes did not correlate with other dataexamined.CONCLUSION:Based on these results,lower levels ofserum calcium might be a pathogenic and prognostic factorin colorectal cancer.
AIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS: Seventy newly diagnosed CRC patients wereincluded.The healthy control group was age and gendermatched (n = 32). Particular attention was devoted to therelationshipbetween serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that couldbe considered as prognostic factors) .Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism wasinvestigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above .RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25 (OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA. 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data. CLUSION: Based on these results, lower levels ofserum calcium might be a pathogenic and prognostic factorin colorectal cancer.