β-卡波林生物碱flazin与冬凌草甲素杂合衍生物的合成及其抗肿瘤活性

来源 :中南民族大学学报（自然科学版） | 被引量 : 0次 | 上传用户：sgcc7186

【摘要】

：

基于β-卡波林生物碱flazin和冬凌草甲素的抗肿瘤活性及分子结构特点,对其进行结构修饰,合成了一系列类似物,并利用活性官能团拼接原理,将二者进行杂合获得杂合衍生物.采用改良MTT法研究了杂合衍生物对肿瘤细胞增殖的影响,初步确定了具有良好细胞毒性的活性分子,为获得更为低毒、高效的抗肿瘤先导化合物提供了线索.

【作者】

：

李莉路明坤连国周义博孙焕刘吉开

【机构】

：

中南民族大学药学院,武汉 430074

【出处】

：

中南民族大学学报（自然科学版）

【发表日期】

：

2021年6期

【关键词】

：

β-卡波林冬凌草甲素杂合化合物抗肿瘤活性

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β-卡波林生物碱flazin与冬凌草甲素杂合衍生物的合成及其抗肿瘤活性

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