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阿米巴原虫可引起一种类似于急性细菌性脑膜炎样的疾病,即原发性阿米巴脑膜脑炎。感染的方式是人在被阿米巴原虫污染的水中游泳时,原虫从鼻粘膜直接侵入大脑所致。本病预后严重,由于脑组织广泛受损,患者可在症状出现后数天内死亡。已知两性霉素B能非常有效地杀灭试管内和小鼠体内的阿米巴原虫,而临床疗效却欠佳,故有人认为病人死亡可能由其它原因所致。作者根据两性霉素B治疗白色念珠菌感染的小鼠,在感染早期用药,则感染得以
Amebic protozoa can cause a disease similar to acute bacterial meningitis-like primary amoebic meningoencephalitis. The infection is caused by the direct invasion of the protozoan from the nasal mucosa when swimming in water contaminated with amoeba. The prognosis of this disease is serious, due to extensive damage to brain tissue, patients may die within a few days after symptoms appear. Amphotericin B is known to kill amoebae in vitro and in mice very effectively, and the clinical efficacy is poor, so some people think that the patient’s death may be caused by other reasons. The author according to amphotericin B treatment Candida albicans infected mice, early infection in the infection, the infection can be