论文部分内容阅读
目的 :制备阿司匹林缓释胶囊 (A -SRC) ,并对其释放度与生物利用度进行研究。方法 :通过测定A -SRC的释放度 ,进行释放机制的研究 ;测定家兔体内血药浓度 ,研究A -SRC的相对生物利用度。结果 :A -SRC体外释放符合零级动力学过程。该制剂相对于其普通片剂释药稳定、生物利用度高。结论 :A -SRC缓释效果明显 ,给药后血药浓度较为平缓 ,持续作用时间长 ,可减少给药次数 ;由于A -SRC采用轻质辅料具漂浮性能 ,缓慢释药 ,因而有利于降低其对胃肠道的刺激性及其他不良反应。
OBJECTIVE: To prepare aspirin sustained-release capsules (A-SRC) and study its release and bioavailability. Methods: The release mechanism of A-SRC was studied by measuring the release of A-SRC. The plasma concentration of A-SRC was measured to study the relative bioavailability of A-SRC. RESULTS: A-SRC release in vitro was in accordance with the zero-order kinetics. The formulation is stable and bioavailable compared to its conventional tablets. CONCLUSIONS: A-SRC has a long-term sustained release effect. After administration, the plasma concentration is relatively gentle and the sustained action time is long, which can reduce the number of administrations. Because A-SRC uses light auxiliary materials to float slowly and release slowly, Its gastrointestinal irritation and other adverse reactions.