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本文用斑点杂交法检测了163例无症状HBsAg携带者及105例HBsAg阴性而抗HBc和(或)抗HBs阳性者血清HBV-DNA,借以比较不同血清标志的传染性。无症状HBsAg携带者HBV-DNA检出率为58.3％,其中HBeAg阳性者为90.8％,抗HBe阳性者为14.7％:HBsAg阴性(抗HBc和/或抗HBs阳性)者中HBV-DNA检出率仅为1.9％.表明HBV-DNA与HBeAg关系最密切,HBV-DNA检出率与HBsAg滴度呈正相关,无性别差异,但与年龄有关,年龄越小HBV-DNA检出率越高。大多数无症状HBsAg携带者血中HBV—DNA阳性可持续9个月以上。
In this study, 163 cases of asymptomatic HBsAg carriers and 105 cases of HBsAg-negative and anti-HBc and / or anti-HBs positive serum HBV-DNA were detected by dot-blot hybridization to compare the infectivity of different serum markers. The detection rate of HBV DNA in asymptomatic HBsAg carriers was 58.3%, of which 90.8% were HBeAg positive and 14.7% were anti-HBe positive: HBV-DNA was detected in HBsAg negative (anti-HBc and / or anti-HBs positive) The rate was only 1.9%, indicating that HBV-DNA was the most closely related to HBeAg. The detection rate of HBV-DNA was positively correlated with HBsAg titer, but no gender difference, but age-related, the younger the higher the detection rate of HBV-DNA. The majority of asymptomatic HBsAg carriers in the blood HBV-DNA positive for more than 9 months.