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目的：探讨鼻咽癌放疗中是否存在肿瘤细胞的加速增殖，为鼻咽癌后程加速超分割治疗提供依据。方法：对放疗3－4周时的鼻咽癌行鼻咽纤维镜活检，利用自动图象分析仪对病理活俭阳性者进行疗前、疗中的细胞增殖动力学参数AgNORS的检测和自身前后计量对照。结果：共得到14对放疗前、放疗中3－4周时的AgNORS检测自身前后对照计量资料进行配对t检验，结果表明放疗中的各参数大于疗前的各参数，疗前、疗中平均每核AgNORS颗粒面积分别为10．19和15．28μm2，平均每核AgNORs颗粒数为12．61和18．09，AgNORs颗粒面积与核面积比值为0．141和0．200，平均每个AgNORs颗粒面积为2．60和3．49，差别具有显著性（P＝0．000～0．010）。结论：鼻咽癌放疗过程存在着肿瘤细胞加速再增殖，这时予以加量加速治疗具有一定的必要性。
Objective: To investigate the accelerated proliferation of tumor cells in radiotherapy of nasopharyngeal carcinoma (NPC) and provide basis for accelerated hyperfractionation of nasopharyngeal carcinoma afterward. Methods: nasopharyngeal fibroscopy was performed on nasopharyngeal carcinoma 3-4 weeks after radiotherapy. AgNORS was used to detect the cell proliferation kinetic parameters before and after treatment with the automatic image analyzer. Measurement control. Results: A total of 14 pre-radiotherapy and radiotherapy 3-4 weeks AgNORS test before and after their own control metrological data paired t-test showed that the parameters of radiation therapy is greater than the parameters before treatment, before and after treatment, the average per Nuclear AgNORS particle area of 10.19 and 15.28μm2, respectively, the average number of AgNORs per core 12.61 and 18.09, AgNORs particle area and nuclear area ratio of 0.141 and 0.200, the average number of each AgNORs particles The area was 2.60 and 3.49, the difference was significant (P = 0.000 ~ 0.010). Conclusion: There is a certain need for accelerating the proliferation of tumor cells in nasopharyngeal carcinoma during radiotherapy.