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目的 探讨对于结肠癌术后的患者,采用长期服用益生菌防治腹泻/消化不良的效果.方法 从我院2014G6-2016G6期间收治的结肠癌需行化疗治疗的患者中,选取其中58例患者作为研究对象,采用随机分组方式,将患者分为观察组和对照组,每组各29例.观察组患者在术后放化疗期间立即给予长期口服双歧三联活菌胶囊治疗,对照组在术后放化疗期间行常规治疗,未长期服用益生菌.比较经过治疗三个月内两组患者出现消化不良/腹泻的发生率.观察组患者在出现消化不良或腹泻时给予口服双歧三联活菌胶囊的同时增加应用蒙脱石散治疗,对照组在患者出现消化不良/腹泻时单纯应用蒙脱石散治疗.在此基础上,两组患者在出现消化不良或腹泻时给予补液等对症支持治疗,比较经过两组中发生消化不良/腹泻的患者治疗前、后,两组患者的KPS(Karnofsky)功能状态评分、消化不良/腹泻的治疗效果.结果统计两组患者经过治疗后的三个月内,发生消化不良/腹泻的发病率可知,观察组患者发生消化不良/腹泻的总发生率为4138%,对照组患者发生消化不良/腹泻的总发生率为8276%,组间数据差异显著(P<005),有统计学意义;统计两组发生消化不良/腹泻的患者中,经过治疗前后的KPS功能状态平均分可知,两组患者经过治疗前,比较KPS功能状态平均分,组间数据未见显著差异(P>005),无统计学意义.经过治疗后,观察组患者的KPS功能状态平均分明显高于对照组患者的KPS功能状态平均分(P<005),有统计学意义;统计两组患者经过治疗后的治疗有效率可知,观察组患者的治疗有效率(9167%)明显高于对照组患者的治疗有效率(3750%),组间数据差异明显,(P<005),有统计学意义.结论 对于结肠癌术后的患者,采用长期服用益生菌防治腹泻以及消化不良的效果较好,但对于处于消化不良及腹泻急性期的患者采用益生菌联合蒙脱石散治疗的效果更为显著.
Objective To investigate the effect of long-term administration of probiotics on the prevention and treatment of diarrhea / dyspepsia in patients with postoperative colon cancer.Methods 58 patients with colon cancer who underwent chemotherapy during 2014G6-2016G6 in our hospital were enrolled in this study. Subjects were randomly divided into observation group and control group.The patients in each group were 29 cases.The patients in observation group were treated with long-term oral Bifidobacterium triple viable capsule after radiotherapy and chemotherapy in the observation group, Chemotherapy during routine treatment, not long-term use of probiotics.Three months after treatment compared the incidence of dyspepsia / diarrhea in both groups of patients in the observation group patients with dyspepsia or diarrhea given oral Bifidobacterium triple viable capsule At the same time, the application of montmorillonite was increased, while the control group was treated with montmorillonite alone in patients with dyspepsia / diarrhea.On the basis of this, two groups of patients were given symptomatic supportive therapy such as rehydration in case of dyspepsia or diarrhea After two groups of patients with dyspepsia / diarrhea before and after treatment, KPS (Karnofsky) functional status scores, dyspepsia / diarrhea Results The incidence of dyspepsia / diarrhea occurred within three months after treatment in both groups showed that the incidence of dyspepsia / diarrhea was 4138% in the observation group and dyspepsia / diarrhea occurred in the control group Of the total incidence of 8276%, significant difference between the two groups of data (P <005), statistically significant; statistics between the two groups of patients with dyspepsia / diarrhea, after treatment KPS functional status of the average score shows that two groups of patients Before treatment, KPS functional status of the average score, no significant difference between groups data (P> 005), no statistically significant after treatment, the observation group patients KPS functional status average score was significantly higher than the control group patients KPS (P <0.05), statistical significance (P <005), statistically significant; after treatment, the two groups of patients treated by statistical analysis shows that the treatment of patients in the observation group (9167%) was significantly higher than the control group 3750%), the difference between the groups was significant (P <005), with statistical significance.Conclusion The effect of long-term use of probiotics in preventing and treating diarrhea and dyspepsia is better for patients with postoperative colon cancer, but for patients with indigestion And acute diarrhea The patients treated with probiotics combined with montmorillonite powder is more effective.