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目的：研究青蒿琥酯对豚鼠哮喘模型的平喘作用。方法：豚鼠组胺与乙酰胆碱引喘法，治疗药物采用雾化吸入和灌胃２种给药途径。结果：雾化或灌胃给药，青蒿琥酯均对药源性哮喘呈现剂量依赖性明显的抑制作用，其半数有效剂量（ＥＤ５０）分别为（９９．９５±７．６９）ｍｇ·Ｌ－１（ｎ＝４）和（１５．６４±１．２５）ｍｇ·ｋｇ－１·ｄ－１（ｎ＝４），其抑制作用与给药的剂量之间呈良好线性关系。结论：青蒿琥酯对豚鼠哮喘模型有一定的平喘作用。
Objective: To study the antiasthmatic effects of artesunate on asthmatic models in guinea pigs. METHODS: Guinea pig histamine and acetylcholine-induced asthma were used. The therapeutic drugs were administered by aerosol inhalation and intragastric administration. RESULTS: Artesunate exhibited a dose-dependent inhibitory effect on drug-induced asthma by aerosolization or intragastric administration. The half effective dose (ED50) was (99.95±7.69) mg·L, respectively. -1 (n=4) and (15.64±1.25) mg·kg-1·d-1 (n=4) showed a good linear relationship between the inhibitory effect and the dose administered. Conclusion: Artesunate has a certain anti-asthmatic effect on guinea pig asthma model.