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目的：了解福建省鼠伤寒沙门氏菌的病原学特征变迁情况。方法：采用噬菌体分型、质粒谱分析及耐药性测定的方法，对福建省１９８０～１９９５年１５年鼠伤寒沙门氏菌的病原学特征进行动态监测。结果：福建省鼠伤寒沙门氏菌的噬菌体流行型别存在明显的变迁与更迭；质粒谱型有逐渐增多且分散趋势；菌株耐药率逐年大幅度上升，耐药谱逐年迅速增宽，多重耐药菌株逐年急剧增多，耐药现象日趋严重。结论：噬菌体分型、质粒谱分析及耐药性测定是监测福建省鼠伤寒沙门氏菌病原学特征变迁趋势的有效方法。
Objective: To understand the etiological characteristics of Salmonella typhimurium in Fujian Province. Methods: The etiological characteristics of Salmonella typhimurium in Fujian province during 1980-1995 were dynamically monitored by phage typing, plasmid analysis and drug resistance assay. Results: The prevalence of Salmonella typhimurium phage in Fujian Province showed obvious changes and changes. Plasmids were gradually increased and dispersed. The drug resistance of the strains increased rapidly year by year, and the spectrum of drug resistance rapidly increased year by year. A sharp increase year by year, drug resistance is worsening. Conclusion: Phage typing, plasmid analysis and drug resistance determination are effective methods to monitor the etiological characteristics of Salmonella typhimurium in Fujian Province.