论文部分内容阅读
目的探讨TP方案化疗同步精确放疗治疗Ⅲ期食管癌的近期疗效、局部控制率、生存率及毒性反应。方法 60例Ⅲ期食管癌患者根据入选标准随机分组,30例进入精确放疗加紫杉醇联合顺铂化疗组(放化组),30例进入精确放疗组(单放组)。单放组采用精确放疗9,5%PTV 56～60GY/28～30次,每周5次。放化组:放疗从第1天即开始采用精确放疗,同时化疗:紫杉醇40mg/m2;第18、1、5d,DDP 30mg,第1～3d静脉滴注,每28d为1周期,共两周期。结果局部近期疗效放化组好于单放组(P<0.05)。放化组1、3年生存率分别为87.7%、47%,单放组分别为82.5%2、1%。两组1年生存率间无明显差异(P>0.05),但3年生存率间差异有统计学学意义(P<0.05)。毒副反应放化组高于单放组,但患者能够耐受。结论以TP方案化疗同步精确放疗治疗Ⅲ期食管癌近期疗效和局部控制率较好,能提高远期生存率可能,虽毒性反应增加但能耐受。
Objective To investigate the short-term curative effect, local control rate, survival rate and toxicological response of TP regimen with concurrent and precise radiotherapy for stage Ⅲ esophageal cancer. Methods Sixty patients with stage Ⅲ esophageal cancer were randomly divided into radiotherapy group, 30 patients underwent radiotherapy with paclitaxel plus cisplatin chemotherapy (radiotherapy group) and 30 patients received radiotherapy (radiotherapy alone group). Radiotherapy group using precise radiotherapy 9,5% PTV 56 ~ 60GY / 28 ~ 30 times a week, 5 times. Radiotherapy: radiotherapy from the first day that began using precise radiotherapy, while chemotherapy: paclitaxel 40mg / m2; 18,1,5 d, DDP 30mg, 1 ~ 3d intravenous infusion every 28d for a period of two cycles . Results The local short-term effect radiotherapy group was better than the single radiotherapy group (P <0.05). The 1-year and 3-year survival rates of radiotherapy group were 87.7% and 47%, respectively, and 82.5% and 2.1% respectively in radiotherapy group. There was no significant difference in one-year survival rate between the two groups (P> 0.05), but the difference of 3-year survival rate was statistically significant (P <0.05). Toxicity group was higher than radiotherapy group, but patients were able to tolerate. Conclusion TP regimen chemotherapy with synchronous and accurate radiotherapy for the treatment of stage Ⅲ esophageal cancer has a good short-term curative effect and local control rate, which can improve the long-term survival rate, although the toxic response increases but can tolerate.