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目的:观察玻璃体切除联合重水保护下内界膜剥除及孔周按摩术治疗特发性黄斑孔的效果。方法:回顾性非随机对照研究。选取2018年6月至2019年12月郑州大学第一附属医院眼二科一组治疗的特发性黄斑孔者35例(37只眼)，均接受玻璃体切除术联合重水保护下内界膜剥除及孔周按摩术。术后随访6个月，观察裂孔闭合情况、视力及并发症。结果:术后37只眼黄斑孔全部闭合。术后1、3及6个月视力(BCVA，logMAR)逐渐改善，由术前的1.02±0.32提高至0.73±0.19、0.59±0.18及0.50±0.18(n F＝79.690，n P<0.001)。除1只眼短暂黄斑水肿，1只眼一过性高眼压外，余均未出现并发症。n 结论:玻璃体切除联合重水保护下内界膜剥除及孔周按摩手术治疗特发性黄斑孔临床疗效确切。“,”Objective:To observe the efficacy of vitrectomy combined with internal limiting membrane peeling and perimacular hole massage under protection of deuterium oxide for idiopathic macular hole.Methods:This was a retrospective non-randomized controlled study. Thirty-seven eyes of 35 patients with idiopathic macular hole from Jun. 2018 to Dec. 2019 in the First Affiliated Hospital of Zhengzhou University were treated with vitrectomy combined with internal limiting membrane peeling and perimacular hole massage under protection of deuterium oxide. The patients were followed up and observed for 6 months. The closure of macular hole, visual acuity and complications were observed.Results:The macular holes were closed in 37 eyes after operation. The visual acuity (BCVA, logMAR) gradually improved from 1.02±0.32 before operation to 0.73±0.19, 0.59±0.18 and 0.50±0.18 at 1, 3 and 6 months after operation (n F=79.690, n P<0.001). There were no other complications except transient macular edema in 1 eye and transient high intraocular pressure in 1 eye.n Conclusion:Vitrectomy combined with internal limiting membrane peeling and perimacular hole massage under protection of deuterium oxide is effective for the treatment of idiopathic macular hole.