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采用 Bessler 胎鼠肝细胞鉴定法测定34例正常人及74例肾脏病患者血清红细胞生成素(SEp)活性,并按不同血红蛋白浓度(Hb)及慢性肾功能不全分期分别与 SEp 进行分析。结果显示:SEp与 Hb 变化、肌酐清除率(Ccr)变化均无相关(P>0.05)。肾功能正常期与其他肾功能不全各期的 SEp 比较均差异不显著(P>0.05)。而正常肾功能及异常肾功能分别与正常人的 SEp 活性比较均有明显降低(P<0.001)。进一步反映了肾实质受损后,体内红细胞生成素有明显减少,但仍然维持一定 SEp 水平。
Serum erythropoietin (SEp) activity was measured in 34 normal subjects and 74 patients with nephrotic syndrome by Bessler fetal rat hepatocyte assay. The levels of SEp were analyzed by different hemoglobin concentrations (Hb) and chronic renal insufficiency. The results showed that there was no correlation between SEp and changes of Hb and creatinine clearance (Ccr) (P> 0.05). There was no significant difference in SEp between normal renal function and other renal insufficiency (P> 0.05). SEp activity of normal renal function and abnormal renal function were significantly lower than that of normal people (P <0.001). Further reflects the renal parenchymal damage, the body significantly reduced erythropoietin, but still maintain a certain level of SEp.