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新斯的明的毒性较低,临床治疗量的副作用极少。我们发现1例应用新斯的明后出现暂时性舌体强直,言语不便,报告如下: 李××,男,19岁,因阵发性室上性心动过速,胸闷、心悸、头晕、失眠(心率140次/分,律齐),给予新斯的明0.5毫克肌注,安定2.5毫克,一日三次口服。注射半小时后,患者自觉舌体膨大,强直,言语不便,但意识清楚。患者既往体健,无类似病史。体检:神清,血压120/70毫米汞柱,心率94次/分,律齐。两肺(-),未引出病理反射。舌体外观无明显异常,但转动及伸舌时僵硬不便,吐语不清,未见流涎。一小时后,症状逐渐缓解。患者曾多次口服安定未见任何反应。
Neostigmine is less toxic and has minimal side effects from clinical treatments. We found that 1 case of neostigmine appeared after temporary tongue stiffness, speech inconvenience, the report is as follows: Lee × ×, male, 19 years old, due to paroxysmal supraventricular tachycardia, chest tightness, heart palpitations, dizziness, insomnia (Heart rate 140 beats / min, law Qi), given neostigmine 0.5 mg intramuscular injection, diazepam 2.5 mg three times a day orally. Half an hour after injection, the patient consciously bulging tongue, ankylosis, speech inconvenience, but the awareness of clear. Past patient health, no similar history. Physical examination: Shen Qing, blood pressure 120/70 mm Hg, heart rate 94 beats / min, law Qi. Both lungs (-) did not elicit pathological reflexes. No significant abnormalities in the appearance of the tongue, but stiff and inconvenient to rotate and stretch the tongue, vomit clearly, no salivation. After one hour, the symptoms gradually eased. Patients have oral orally stable many times without any response.