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目的研究被动吸烟孕妇血浆白细胞介素6(interleukin-6,IL-6)和白细胞介素10(interleukin-10,IL-10)在孕期的变化,探讨其与早产之间的关系。方法选取155例早产孕妇(28~36+6周)为研究组,并根据有无存在被动吸烟分成两组,研究组1为被动吸烟组,研究组2在妊娠期间无被动吸烟或吸烟;同时选取82例对照组孕妇(妊娠期无被动吸烟或吸烟且最后足月分娩的产妇)。采用酶联免疫吸附法,测定研究组1、2孕妇及对照组孕妇在相应孕周时的血浆IL-6和IL-10浓度。结果研究组1孕妇血浆IL-6浓度较研究组2和对照组明显升高(P<0.05);而研究组1孕妇IL-10浓度较在研究组2降低,但其变化无显著意义(P>0.05);研究组孕妇IL-10较对照组明显下降(P<0.05)。结论孕期被动吸烟可致IL-6明显升高,及IL-10呈下降趋势,可能参与了被动吸烟引发早产高风险的机制,增加早产的发生风险。
Objective To study the changes of plasma levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) during pregnancy in passive smoking pregnant women and to explore their relationship with preterm birth. Methods 155 pregnant women with preterm birth (28-36 + 6 weeks) were selected as study group and divided into two groups according to the presence or absence of passive smoking. Study group 1 was passive smoking group and study group 2 had no passive smoking or smoking during pregnancy. At the same time Select 82 pregnant women in the control group (no passive smoking during pregnancy or smoking and the last full-term delivery of mothers). Enzyme-linked immunosorbent assay was used to determine plasma IL-6 and IL-10 levels in pregnant women in the study group 1, 2 and pregnant women at the corresponding gestational weeks. Results The level of plasma IL-6 in study group 1 was significantly higher than that in study group 2 and control group (P <0.05), while the concentration of IL-10 in study group 1 was lower than that in study group 2 (P <0.05), but the change was not significant > 0.05). IL-10 in study group was significantly lower than that in control group (P <0.05). Conclusion Passive smoking during pregnancy may lead to a significant increase of IL-6 and a decrease of IL-10, which may be involved in the mechanism of high risk of premature birth induced by passive smoking and increase the risk of premature birth.