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雄性山羊１４只，随机分为高渗氯化钠溶液治疗组ＨＳ（ｎ＝８）和生理盐水治疗组ＮＳ（ｎ＝６）．在模拟４０００ｍ高原环境停留２４ｈ后，经股动脉放血，使动脉平均压降至５．５±０．３２ｋＰａ，并维持６０ｍｉｎ．然后夹闭放血管，两组分别经股静脉输入４ｍ１／ｋｇ的高渗氯化钠溶液或生理盐水．结果表明，输入高渗氯化钠溶液后心输出量、动脉平均压、ＣｖＯ_２、ＡＢ、ＢＥ逐渐恢复并接近对照值．提示ＨＳ组动物的存活时间长和存活率高，可能与血浆钠离子浓度增加从而增强心肌收缩力，提高有效循环血量，改善组织的氧供应和部分纠正代谢性酸中毒有关．
Fourteen male goats were randomly assigned to HS (n = 8) and NS (n = 6) treated with hypertonic sodium chloride solution. After simulating the 4000m altitude environment for 24 hours, the average arterial pressure dropped to 5.5 ± 0.32kPa via the femoral artery and maintained for 60min. Then clamp the tube, the two groups were fed via the femoral vein 4ml / kg of hypertonic sodium chloride solution or saline. The results showed that cardiac output, mean arterial pressure, CvO_2, AB, BE gradually recovered and approached the control value after the hypertonic sodium chloride solution was infused. These results suggest that animals in HS group have longer survival time and higher survival rate, which may be related to the increase of sodium ion concentration in plasma to enhance myocardial contractility, increase effective circulating blood volume, improve tissue oxygen supply and partially correct metabolic acidosis.