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吗丁啉为一种外周多巴胺受体阻滞剂,可直接作用于胃肠壁,增强胃蠕动,促进胃排空,抑制恶心呕吐,作为新型胃动力药,临床应用日渐广泛,现将三家医院4例小儿神经系统毒性反应报告如下。 例1,浙江医大儿童医院病例,女,4个月,因腹泻一周伴低热以小诺霉素和吗丁啉治疗,用吗丁啉总量20mg后出现神志不清,颈强,两眼凝视,四肢肌张力增高,无病理反射征,无脱水征,血气及血生化正常,入院后停用吗丁啉,12小时后神志清
As a peripheral dopamine receptor blocker, domperidin can act directly on the gastrointestinal wall, enhance gastric motility, promote gastric emptying, inhibit nausea and vomiting, as a new gastric motility drug, clinical application is increasingly widespread, now the three hospitals 4 cases of pediatric nervous system toxicity report as follows. Case 1, Zhejiang Medical University Children’s Hospital cases, female, 4 months, due to diarrhea with fever and metamictin week with minotherapy, the total amount of 40mg after morphine confusion, neck strong, staring at both eyes , Limb muscle tone increased, no pathological reflex sign, no signs of dehydration, blood gas and blood biochemical normal, disabled after admission morphine, 12 hours later,