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目的:探讨胃癌高发区CagA+H pylori茵株与胃黏膜病变的相关性. 方法:对216例H pylori阳性的普通人群,行胃镜检查及胃黏膜HE染色明确胃黏膜病理学改变,同时用蛋白芯片技术检测H pylori的CagA抗体. 结果:在216例标本中,浅表性胃炎23例,萎缩性胃炎189 例,中度以上萎缩性胃炎164例,占75.93%(164/216),中度以上肠上皮化生(IM)31例,占14.81%(31/216),中度以上畀型增生33例,占15.28%(33/216),胃癌4例.萎缩性胃炎、中度以上肠上皮化生和异型增生组CagA+H pylori阳性率均较浅表性胃炎组显著升高(71.43%,67.74%,72.73% vs 17.39%, P<0.05). 结论:CagA+H pylori具有较强的促进胃黏膜萎缩、肠型化生和异型增生作用,感染CagA+Hpylori可能是胃癌发生的危险因素之一.
Objective: To investigate the correlation between CagA + H pylori strain and gastric mucosal lesions in high incidence area of gastric cancer.Methods: 216 cases of H pylori-positive general population were examined by gastroscopy and gastric mucosa HE staining to clarify the pathological changes of gastric mucosa, Chip technique was used to detect the CagA antibody of H pylori.Results: In 216 samples, there were 23 cases of superficial gastritis, 189 cases of atrophic gastritis, 164 cases of moderate to severe atrophic gastritis, accounting for 75.93% (164/216), moderate (IM) in 31 cases, accounting for 14.81% (31/216), 33 cases of moderate hyperplasia, accounting for 15.28% (33/216), 4 cases of gastric cancer, atrophic gastritis, moderate to severe upper intestine The positive rates of CagA + H pylori in epithelial metaplasia and dysplasia group were significantly higher than those in superficial gastritis group (71.43%, 67.74%, 72.73% vs 17.39%, P <0.05) .Conclusion: CagA + Of gastric mucosal atrophy, intestinal metaplasia and dysplasia, infection CagA + Hpylori may be one of the risk factors for gastric cancer.