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目的：研究重组白细胞介素２（ｒＩＬ－ ２） 对下丘脑－ 垂体－ 肾上腺轴的作用。方法：采用ｒＩＬ－ ２ 静脉注入（Ｂ组注入前用抗－ ＣＲＨ 血清预处理） ，测定注入ｒＩＬ－ ２ 后不同时间ＣＲＨ，ＡＣＴＨ 及ＣＯＲＴ 血浆含量变化。结果：ｒＩＬ－ ２ 可使不同水平的ＣＲＨ，ＡＣＴＨ，ＣＯＲＴ 血浆含量升高（Ａ 组）（ Ｐ＜ ０－０１） ，当预先注入抗－ ＣＲＨ 血清后ＡＣＴＨ、ＣＯＲＴ 的升高不被阻断（Ｂ 组） 。结论：ｒＩＬ－ ２ 对ＨＰＡＡ 的激活作用不是通过ＣＲＨ 介导的
AIM: To investigate the effect of recombinant interleukin-2 (IL-2) on hypothalamic-pituitary-adrenal axis. Methods: The plasma levels of CRH, ACTH and CORT at different time after rIL - 2 injection were measured by rIL - 2 intravenous injection (group B before anti - CRH serum pretreatment). Results: Plasma levels of CRH, ACTH and CORT at different levels were increased by rIL-2 (group A) (P <0-01). The increase of ACTH and CORT was not blocked after pretreatment with anti-CRH serum Group B). Conclusion: The activation of rAAV-2 on HPAA is not mediated by CRH