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在使用免疫抑制剂治疗的患者中,血液系恶性病变发生率增高。本文研究长期使用硫唑嘌呤治疗的患者骨髓象,观察其形态学与分裂指数的变化是否对血液系恶性病变发生的诊断与预后有价值。病例:肾脏病组(慢性肾小球肾炎)男4,女3。接受硫唑嘌呤0.6～1.3mg/kg·日,5～12年。肾移植组男9,女9。接受硫唑嘌呤1.4～2.0mg/kg·日,3～5年。无1例缺乏维生素B_(12)及叶酸。对照组男9,女11,为非血液病患者。
In patients treated with immunosuppressive agents, the incidence of hematological malignancies increased. In this paper, long-term use of azathioprine treatment of patients with bone marrow, to observe whether the changes in morphology and mitotic index of hematological malignancies diagnosis and prognosis of the value. Case: kidney disease group (chronic glomerulonephritis) male 4, female 3. Azathioprine received 0.6 ~ 1.3mg / kg · day, 5 to 12 years. Kidney transplantation group male 9, female 9. Azathioprine received 1.4 ~ 2.0mg / kg · day, 3 to 5 years. No cases of lack of vitamin B_ (12) and folic acid. Control group male 9, female 11, non-hematological diseases.