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目的探讨促酰化蛋白(acylation stimulating protein,ASP)基因301T>C多态性与新疆地区维吾尔族冠心病及血脂的关系。方法 385例冠心病患者(冠心病组)与483例冠状动脉造影结果阴性患者(对照组),2组采用聚合酶链反应-限制性片段长度多态性技术检测301T>C多态性,并检测其血脂水平。结果冠心病组ASP基因301T>C的3种基因型分布频率分别为TT型44.7%、CT型43.1%、CC型12.2%;对照组分别为TT型53.8%、CT型40.2%、CC型6.0%,2组基因型分布差异有统计学意义(P<0.01);Logistics回归分析结果显示,CC基因型个体患冠心病风险是TT基因型的0.784倍(OR=2.189,95%CI:1.251～3.830);冠心病组301T>C基因型亚组间三酰甘油水平差异有统计学意义(P<0.05);CC基因型三酰甘油水平高于TT基因型(P<0.05)。结论 ASP基因301T>C多态性与新疆维吾尔族人群冠心病的发生有一定相关性,CC基因型可能是冠心病发生的危险因素之一。
Objective To investigate the relationship between 301T> C polymorphism of acylation stimulating protein (ASP) gene and coronary heart disease and blood lipid in Uighur in Xinjiang Uygur Autonomous Region. Methods 385 patients with coronary heart disease (CHD) and 483 patients with negative coronary angiography (control group) were enrolled. Two groups were examined for 301T> C polymorphism by polymerase chain reaction-restriction fragment length polymorphism Test its blood lipid levels. Results The distribution frequencies of 301T> C genotypes in CHD patients were 44.7% for TT, 43.1% for CT and 12.2% for CC, respectively. The control group was 53.8% for TT, 40.2% for CT and 6.0% for CC (P <0.01). Logistics regression analysis showed that the risk of coronary heart disease was 0.784 times of that of TT genotype (OR = 2.189, 95% CI: 1.251 ~ 3.830). The triglyceride level in 301T> C genotype subgroup of CHD patients was significantly different (P <0.05). The CC genotype triglyceride level was higher than TT genotype (P <0.05). Conclusion The 301T> C polymorphism of ASP gene is associated with the occurrence of coronary heart disease in Xinjiang Uighur population. CC genotype may be one of the risk factors of coronary heart disease.