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目的:观察腹腔穿刺并单腔中心静脉导管置管引流联合腹腔内使用复方苦参注射液和顺铂治疗恶性腹腔积液的疗效和安全性。方法:将68例经病理证实的恶性腹腔积液患者分为A、B组,均行腹腔穿刺置管引流,后腹腔使用药物。A组39例患者腹腔内使用复方苦参注射液和顺铂,B组29例患者腹腔内单纯使用顺铂。观察2组的临床疗效和不良反应。结果:A组治疗恶性腹腔积液的总有效率为79.8%,显著优于B组(48.3%),2组比较差异有统计学意义(P<0.05)。2组患者的不良反应主要为消化道反应,组间比较无显著性差异(P>0.05)。结论:腹腔穿刺并单腔中心静脉导管置管引流联合腹腔内使用复方苦参注射液和顺铂治疗恶性腹腔积液较单用顺铂有效。
Objective: To observe the efficacy and safety of abdominal puncture combined with single-lumen central venous catheter drainage and intraperitoneal injection of compound Kushen injection and cisplatin in the treatment of malignant ascites. Methods: A total of 68 patients with malignant ascites confirmed by pathology were divided into group A and group B. All patients underwent peritoneal catheterization and drainage and were given intraperitoneal drugs. A group of 39 patients intraperitoneally with compound Kushen injection and cisplatin, B group 29 patients intraperitoneally with cisplatin alone. The clinical efficacy and adverse reactions of the two groups were observed. Results: The total effective rate of treatment of malignant ascites in group A was 79.8%, which was significantly better than that in group B (48.3%). The difference between the two groups was statistically significant (P <0.05). Adverse reactions of the two groups were mainly gastrointestinal reactions, with no significant difference between the two groups (P> 0.05). Conclusions: Peritoneal puncture and single-lumen central venous catheter drainage combined intraperitoneal injection of compound Kushen injection and cisplatin in the treatment of malignant ascites than cisplatin alone is effective.