论文部分内容阅读
目的：评估不同使用量的头孢噻肟钠-舒巴坦钠复合制剂与鲍曼不动杆菌耐药的相关性。方法：将经生化分析和药敏鉴定的114株痰培养鲍曼不动杆菌随机分为实验组和对照组。实验组（57株）采用头孢噻肟钠-舒巴坦钠复合制剂抑菌，对照组（57株）采用头孢噻肟钠单方制剂抑菌，依据不同抗菌药平均每天每100床患者用药的频率和同期对鲍曼不动杆菌的耐药率变化，对两组抗菌药物使用量与耐药率进行相关性统计分析。结果：实验组对鲍曼不动杆菌的平均耐药率为42.4%，对照组的耐药率为63.5%。头孢噻肟钠-舒巴坦钠复方制剂与鲍曼不动杆菌对该药耐药率正相关（P=0.0288）；头孢噻肟钠单方制剂与鲍曼不动杆菌耐药率也正相关（P=0.0093）。相对于单方制剂用药，复方用药可有效改善耐药菌对抗菌药的敏感性。结论：头孢噻肟钠-舒巴坦钠抗菌药物使用量与鲍曼不动杆菌耐药性存在相关性，且随着抗菌药使用量的增加，细菌的耐药性越大。“,” Objective: To assess the correlation between consumption of cefotaxime sodium-sulbactam sodium and resistance rates of Acinetobacter baumannii. Methods: 114 strains of Acinetobacter baumanni , confirmed by biochemical analysis and drug susceptibility test, were randomly assigned to experiment group(n=57, cefotaxime sodium-sulbactam sodium were administered ) or control group(n=57, cefotaxime sodium only was administered ). According to antibacterial consumption which defined as daily doses per 100 bed-days and the resistance rate of Acinetobacter baumanni , the correlation was statistically analyzed between the two groups. Results: The average resistance rate against acinetobacter baumanni in the experimental group was 42.4%, the control group was 63.5%.The resistance to consumption of cefotaxime sodium-sulbactam sodium was significantly correlated with resistance to baumanni (P=0.0288). The consumption of cefotaxime sodium was significantly correlated with resistance to baumanni (P=0.0093). As compared with cefofarime only,cefofaxime sodium-sulbactan sodium can effectively improve the sensitivity of the resistant bacteria to antimicrobial drugs. Conclusion:There is a relationship between antibacterial consumption and resistance rates of acinetobacter baumanni , and with the increased use of antimicrobial drugs, the bacterial resistance is stronger.