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目的:观察服用六味地黄汤后绝经后骨质疏松患者骨密度及椎体压缩性骨折发生率,从而评估其临床疗效。方法:60例绝经后骨质疏松患者随机分为对照组和治疗组,每组30例且均给予钙剂治疗,治疗12个月,治疗组同时服用六味地黄汤,分别在治疗前、治疗中6个月及12个月时测量骨密度的变化结果,随访2年,观察椎体压缩性骨折的发生率。结果:2组患者在治疗6个月后腰椎骨密度有所提高,但治疗组提高幅度更大(P<0.05),治疗12个月后治疗组的腰椎骨密度得以继续维持(P<0.05),而对照组则较治疗前无明显变化(P>0.05)。2年后治疗组椎体压缩性骨折发生率为3.33%,而对照组发生率为10.34%。结论:六味地黄汤对绝经后骨质疏松患者治疗有确切效,同时可降低椎体压缩性骨折发生率。
OBJECTIVE: To observe the bone mineral density (BMD) and the incidence of vertebral compression fractures in postmenopausal osteoporosis patients treated with Liuwei Dihuang Decoction, and to evaluate its clinical efficacy. Methods: Sixty postmenopausal osteoporosis patients were randomly divided into control group and treatment group, 30 cases in each group were given calcium treatment for 12 months. The treatment group took Liuweidihuang Decoction at the same time, The changes of BMD at 6 months and 12 months were followed up for 2 years to observe the incidence of vertebral compression fractures. Results: The BMD of lumbar vertebra increased after 6 months of treatment in both groups, but the treatment group increased more significantly (P <0.05). After 12 months of treatment, the lumbar BMD of the treatment group continued to be maintained (P <0.05) , While there was no significant difference in the control group before treatment (P> 0.05). Two years later, the incidence of vertebral compression fractures in the treatment group was 3.33%, while that in the control group was 10.34%. Conclusion: Liuwei Dihuang Decoction has definite effect on the treatment of postmenopausal osteoporosis patients, and can reduce the incidence of vertebral compression fractures.