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目的评价孕妇血清胎盘生长因子在孕早期唐氏综合征产前筛查的应用价值。方法选择2011年1月至2013年11月于孕11~13+6周在广州市妇女儿童医疗中心接受孕早期唐氏筛查孕妇252例作为研究对象。所有孕妇接受孕妇血清妊娠相关蛋白A(PAPPA)、游离人绒毛膜促性腺激素β亚单位(freeβ-h CG)、胎盘生长因子(PLGF)检测。结果唐氏综合征胎儿孕妇血清中PAPPA和PLGF的中位数倍数值分别比对照组低59.5%和35.1%,freeβ-h CG的中位数倍数值比对照组高99.2%,差异均有统计学意义(P<0.05)。以1/270作为高风险截断值,血清三联筛查(游离h CGβ+PAPP-A+Pl GF)和二联筛查(游离h CGβ+PAPP-A)的检出率(DR)分别为85.7%和81.0%。血清三联筛查检出率高于二联筛查。结论孕妇PLGF在孕早期唐氏综合征产前筛查中具有潜在的应用价值,包括Pl GF的血清三联标志物筛查有利于提高血清学筛查的检出率。
Objective To evaluate the value of serum placenta growth factor in prenatal screening of Down’s syndrome in the first trimester of pregnancy. Methods From January 2011 to November 2013, 252 pregnant women receiving Down’s syndrome during the first trimester of pregnancy were enrolled in Guangzhou Women and Children’s Medical Center during the 11th ~ 13th + 6th weeks of pregnancy. All pregnant women received serum pregnancy-associated protein A (PAPPA), free β-h CG, and placental growth factor (PLGF). Results The median multiple of PAPPA and PLGF in serum of pregnant women with Down’s syndrome was 59.5% and 35.1% lower than that of control group respectively. The median multiple of freeβ-h CG was 99.2% higher than that of control group, with statistical differences Significance (P <0.05). The detection rate (DR) of serum triple screening (free h CGβ + PAPP-A + Pl GF) and dual screening (free h CGβ + PAPP-A) % And 81.0%. Triple detection of serum triple detection rate is higher than the second screening. Conclusions PLGF in pregnant women has potential value in prenatal screening of Down’s syndrome in early pregnancy. Screening serum triple markers including Pl GF is helpful to improve the detection rate of serological screening.