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目的探讨瘦素受体基因SNP rs1137101多态分布与儿童肥胖之间的关联。方法对1682名上海某区小学学龄儿童进行身高、体重、腰围测量,及瘦素受体基因SNP rs1137101多态位点基因型分析,通过非条件Logistic回归、卡方检验等方法分析该基因位点多态分布与体重指数(BMI)、腰围身高比(WHtR)等肥胖相关参数之间的关系。结果该人群LEPR基因SNP rs1137101多态位点基因型AA、AG及GG频率分别为0.012、0.224、0.764,等位基因A和G的分布频率分别为0.14和0.86,符合Hardy Weinberg遗传平衡定律(∑X2=1.301,p>0.05);调整性别、年龄、学校所在地区后,AA/AG组和GG组中超重率分别为13.1%和9.1%,其OR值为1.43(95%CI:0.97-2.10,p=0.074),BMI高组和低组中AA/AG基因型携带者比例分别为26.3%和21.1%,其OR值为1.30(95%CI:1.01-1.68)。结论 LEPR基因SNP rs1137101多态位点携带A等位基因与中国学龄儿童超重及高BMI相关,是该人群肥胖的易感因素之一。[营养学报,2012,34(6):536-539]
Objective To investigate the association between polymorphism of SNP rs1137101 and childhood obesity in leptin receptor gene. Methods A total of 1682 primary school-age children in a certain district of Shanghai were surveyed with height, weight, waist circumference and SNP rs1137101 polymorphism locus genotype of leptin receptor gene. The gene locus was analyzed by non-conditional logistic regression and chi-square test Polymorphism and body mass index (BMI), waist circumference ratio (WHtR) and other obesity-related parameters. Results The frequency of AA, AG and GG genotypes of SNP rs1137101 polymorphism in LEPR gene was 0.012, 0.224 and 0.764, respectively. The distribution frequencies of alleles A and G were 0.14 and 0.86, respectively, which were consistent with Hardy Weinberg genetic equilibrium X2 = 1.301, p> 0.05). After adjustment for gender, age and school area, the overweight rates in AA / AG and GG groups were 13.1% and 9.1%, respectively, with an OR of 1.43 (95% CI: 0.97-2.10 , p = 0.074). The proportion of AA / AG genotype carriers in high and low BMI group was 26.3% and 21.1% respectively, with an OR of 1.30 (95% CI: 1.01-1.68). Conclusions The A allele of SNP rs1137101 polymorphism in LEPR gene is associated with overweight and high BMI in Chinese school-age children and is one of the predisposing factors of obesity in this population. [Journal of Nutrition, 2012,34 (6): 536-539]