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去甲肾上腺素（ＮＥ）５ｍｇ·ｋｇ￣（－１）ｉｐ和赛拉嗪１－２ｍｇ·ｋｇ￣（－１）ｓｃ可抑制小鼠排便，而甲氧明（Ｍｅｔ）１５ｍｇ·ｋｇ￣（－１）ｓｃ，异丙肾上腺素１０ｍｇ·ｋｇ￣（－１）ｓｃ多巴酚丁胺２０ｍｇ·ｋｇ￣（－１）ｓｃ和沙丁胺醇５ｍｇ·ｋｇ￣（－１）ｓｃ无效、Ｍｅｔ１５０μｇｉｃｖ也抑制排便。咪唑克生１ｍｇ·ｋｇ￣（－１）ｓｃ可拮抗ＮＥ，赛拉嗪和ｉｃｖＭｅｔ引起的排便抑制，哌唑嗪１ｍｇ·ｋｇ￣（－１）ｓｃ和普萘洛尔１０ｍｇ·ｋｇ￣（－１）ｓｃ则无效。这提示ＮＥ和ｉｃｖＭｅｔ抑制小鼠排便是作用于肠α＿２肾上腺素受体所致。
Norepinephrine (NE) 5mg · kg ~ (-1) ip and xylazine 1-2mg · kg ~ (-1) sc can inhibit mice defecation, while 15mg · kg Met (Met) 1 sc, isoproterenol 10 mg · kg -1 sc scutobutamine 20 mg · kg -1 sc and salbutamol 5 mg · kg -1 sc ineffective, and Met 150 μgicv also inhibited defecation. Midazolam at 1 mg · kg -1 sc counteracted NE, xylazine and icvMet-induced defecation inhibition, prazosin 1 mg · kg -1 (sc) and propranolol 10 mg · kg -1 Sc is invalid. This suggests that NE and icvMet inhibit mouse defecation is caused by the role of intestinal α_2 adrenergic receptors.