论文部分内容阅读
内源性一氧化氮(NO)由几种类型的NO合成酶经L-精氨酸合成。某些同功酶可由炎性细胞活素诱发。作者测定了哮喘患者和非哮喘患者呼出的NO。 67名不吸烟志愿者(男40,女27,平均年龄36岁)作为对照组,哮喘患者患可逆性气道阻滞,研究前至少2周病情稳定。一组接受不定期治疗或仅吸入β_2激动剂(男46,女15,平均年龄32岁),另一组定期接受吸入类固醇(二丙酸氢地米松或budesonide400～1600μg/d,男33,女22,平均年龄44岁)。非类固醇治疗组的平均FEV_1分别为98％和77％。呼出的NO经
Endogenous nitric oxide (NO) is synthesized by L-arginine from several types of NO synthase. Some isozymes may be induced by inflammatory cytokines. The authors measured exhaled NO in asthmatic and non-asthmatic patients. Sixty-six non-smoking volunteers (40 males, 27 females, mean age 36 years) were included in the control group. Patients with asthma had reversible airway block and were stable at least 2 weeks prior to the study. One group received either untreated or inhaled beta 2 agonists (male 46, female 15, mean age 32 years) and the other group received regular inhaled steroids (budesonide dipropionate or budesonide 400-1600 μg / day, males 33 and females 22, average age 44 years old). The mean FEV 1 for the non-steroid treatment group was 98% and 77%, respectively. Exhaled NO by