,The PilZ domain of MrkH represents a novel DNA binding motif

• 作 者: Feng Wang Qing He Kaixuan Su Fei Gao Yan Huang Zong Lin Deyu Zhu
• 机 构: State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China“,”Department
• 出 处: 蛋白质与细胞
• 发表日期: 2016年10期

Dear Editor,MrkH is the first characterized c-di-GMP related transcriptional regulator which affects type 3 fimbrial expression in response to cellular c-di-GMP level,and thus plays an important role in the biofilm formation of Klebsiella pneumoniae (Murphy and Clegg,2012;Wilksch et al.,2011).However,how MrkH recognizes c-di-GMP and the target DNA sequence remains obscure.