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迄今宁愿取绒毛标本用于诊断妊娠8～11周胎儿的遗传学异常,而不是在16～20周了。但这种操作的危害尚未肯定。本文报告1例可能局限在绒毛的染色体嵌合型。病例报告一位38岁(孕7产3)的健康妇女,因年龄而行产前诊断。既往有三次自然流产,夫妇二人的核型正常。超声波检查证实孕龄,并未发现异常。孕10周时在超声波指引下,用约2ml RPMI 1640培养液/1%肝素充盈于可弯曲的导管,通过宫颈采取绒毛40mg,绒毛被放到2个35mm陪替氏培养皿:一个含2.3ml RPMI 1640,以直接法制备染色体;另一个含1.8ml RPMI1640加0.5ml胎牛血清,培
So far rather to take the villus specimens for the diagnosis of fetal gestational 8 to 11 weeks of genetic abnormalities, rather than in 16 to 20 weeks. But the dangers of this operation is yet to be confirmed. This article reports a case of chromosomal chimera that may be confined to villi. Case Report A 38-year-old healthy woman, 7 years old, with prenatal diagnosis due to her age. Past three natural abortion, the couple normal karyotype. Ultrasound confirmed gestational age, did not find abnormalities. At 10 weeks of gestation, about 2 ml of RPMI 1640 medium / 1% heparin was infused under flexible ultrasound in a flexible catheter at 10 weeks of gestation, 40 mg of villi were taken through the cervix, and the villi were placed in two 35 mm Petri dishes: one containing 2.3 ml RPMI 1640, direct chromosome preparation; the other containing 1.8ml RPMI1640 plus 0.5ml fetal bovine serum, culture