Ginsenoside Rg1 protects against is chemiareperfusion-induced neurotoxicity throughmiR-144/Nrf2/ARE

• 作 者: CHU Shi-feng ZHANG Zhao ZHOU X
• 机 构: StateKeyLaboratoryofBioactiveSubstancesandFunctionsofNaturalMedicines,ShanxiKeyLaboratoryofChineseMe
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2018年9期
• 关键词: GINSENOSIDE RG1 ISCHEMIA REPERFUSION NF-E2-related factor 2 antioxidant response
• 基金项目: National Natural Science Foundation of China(81603315,81730096,81373551,81730093,U1402221),CAMS Innovation Fund for MedicalSciences (CIFMS) (2016-I2M-1-004),the Opening Program of Shanxi Key Laborator

OBJECTIVE Ginsenoside Rg1 (Rg1), a purified compound from Panax ginseng, has been well documented to be effective against ischemia/reperfusion (I/R) neurotoxicity. However, the underlying mechanism is still obscure. METHODS The anti-I/R effect of Rg1 were