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目的:探讨胆管癌组织中自发性细胞凋亡现象的意义。方法:TUNEL染色结合形态观察原位检测凋亡细胞。结果:40例胆管癌标本的中位SAI高达7.89%,高/中分化和无淋巴结转移胆管癌的SAI分别显著高于低分化和淋巴结转移者(P<0.001)。结论:胆管癌仍保留有相对活跃的细胞凋亡机制,SAI可作为判断胆管癌恶性程度的有益指标。
Objective: To investigate the significance of spontaneous apoptosis in cholangiocarcinoma. Methods: TUNEL staining and morphological observation were used to detect apoptotic cells in situ. Results: The median SAI of 40 cases of cholangiocarcinoma was as high as 7.89%. The SAI of high / moderately differentiated and non-lymph node metastatic cholangiocarcinoma were significantly higher than those of poorly differentiated and lymph node metastasis (P <0.001). Conclusion: Bile duct cancer still retains a relatively active mechanism of apoptosis, SAI can be used as a useful indicator to determine the degree of malignancy of cholangiocarcinoma.