论文部分内容阅读
目的测定胃癌患者血浆血管性血友病因子(vWF)及血栓调节蛋白(TM)的水平并分析其临床意义。方法采用酶联免疫法测定48例胃癌患者及35例正常人血浆vWF及TM含量,并分析它们与临床的关系。结果胃癌患者血浆vWF及TM含量均显著高于正常对照组(P<0.01);且胃癌Ⅲ、Ⅳ期患者血浆vWF及TM含量显著高于胃癌Ⅰ、Ⅱ期患者(P<0.01)。合并感染、术后复发者及术前胃癌患者血浆vWF及TM含量分别显著高于未合并感染者、术后未复发者及手术后者(P<0.01)。结论胃癌患者内皮功能明显受损,且与临床预后密切相关。
Objective To determine the levels of plasma vWF and TM in patients with gastric cancer and analyze their clinical significance. Methods The plasma levels of vWF and TM in 48 patients with gastric cancer and 35 healthy controls were determined by enzyme-linked immunosorbent assay (ELISA), and their relationship with clinical status was analyzed. Results The plasma levels of vWF and TM in gastric cancer patients were significantly higher than those in normal controls (P <0.01). The plasma levels of vWF and TM in patients with stage Ⅲ and Ⅳ gastric cancer were significantly higher than those in patients with stage Ⅰ and Ⅱ gastric cancer (P <0.01). The plasma levels of vWF and TM in patients with recurrent infection, postoperative recurrence and preoperative gastric cancer were significantly higher than those without infection, postoperative recurrence and postoperation (P <0.01). Conclusion Endothelial function in patients with gastric cancer is significantly impaired, and is closely related to clinical prognosis.