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目的探讨鼻咽癌（ＮＰＣ）肿瘤中微血管计数（ＭＶＣ）与其生物学行为的关系。方法应用免疫组织化学ＬＳＡＢ法，对１０５例具有完整临床资料的鼻咽癌组织及１５例鼻咽部粘膜慢性炎症的石蜡块进行血管内皮细胞ＣＤ３４标记；在病理彩色图文分析系统（ＣＩＡＳ），免疫组织化学专项分析中进行血管计数统计。结果１５例鼻粘膜慢性炎症组织中ＭＶＣ为２３．４３±４．１８，１０５例ＮＰＣ组织中ＭＶＣ为４２．６９±１１．５１，鼻咽癌ＭＶＣ较慢性炎症对照组明显升高，且具有显著性差异（Ｐ＜０．００１）；１０５例ＮＰＣ病例中颈淋巴结转移６７例，ＭＶＣ为４６．３２±１０．７４，无淋巴结转移３８例，ＭＶＣ为３６．２９±１０．０２，两组之间有显著性差异（Ｐ＜０．０１）；但１０５例ＮＰＣ病例中组织学分型间的ＭＶＣ没有显著性差异。结论提示ＭＶＣ可作为预测鼻咽癌早期颈淋巴结转移的一个指标。
Objective To investigate the relationship between microvessel count (MVC) and its biological behavior in nasopharyngeal carcinoma (NPC). Methods The immunohistochemical LSAB method was used to detect the CD34 of vascular endothelial cells in 105 cases of nasopharyngeal carcinoma with complete clinical data and 15 cases of chronic inflammation of nasopharyngeal mucosa. In the pathological color imaging analysis system (CIAS) Immunohistochemistry special analysis of blood count statistics. Results The MVC in 15 cases of chronic inflammation of nasal mucosa was 23.43 ± 4.18, the MVC in 42 cases of NPC was 42.69 ± 11.51, and the MVC of nasopharyngeal carcinoma was significantly higher than that of chronic inflammation group (P <0.001). There were 67 cases of cervical lymph node metastasis in 105 cases of NPC, the MVC was 46.32 ± 10.74, there were 38 cases without lymph node metastasis and 36.29 ± 10.02 with MVC, (P <0.01). However, there was no significant difference in MVC between histological types in 105 NPC cases. Conclusions MVC can be used as a predictor of early cervical lymph node metastasis of nasopharyngeal carcinoma.